Samphire
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Bringing women’s healthcare out of the dark ages.

Applying brain-based technologies to the bodies science overlooked.

A new perspective starts in the brain, and results in real care.

Research Pipeline

Most women’s health conditions can be targeted through brain-based approaches. Even when the cause lies outside the brain, these approaches offer lasting symptom relief -- increasing patient dignity and control while deeper research continues.

Our flagship solution, Nettle, has been subject to multiple clinical trials, with a comprehensive pipeline of follow-up studies planned.

Women's health has been underfunded and overlooked.

We use neuroscience, clinical technology and thoughtful design to create tools that help you feel more clear, steady and in control. From brain fog, to burn out and beyond.

The system's catching up.

Women's health isn't niche. It's necessary.

Pilots and Trials

We’re working with clinical partners, researchers and regulators around the world on a growing portfolio of clinical trials and healthcare system pilots. Below are just a few in progress or complete.

WIND

Testing Nettle™ for PMS and dysmenorrhea.

ENHANCE

Studying Nettle™’s impact on endometriosis-related chronic pelvic pain.

PMDD

Evaluating Nettle™ for Premenstrual Dysphoric Disorder.

RELIEF

Studying Nettle™’s impact on endometriosis-related chronic pelvic pain.

HOPE

Investigating Nettle for pain, fatigue, and quality of life among endometriosis patients.

HOLD

Evaluating the longer-term impact of Nettle™ for menstrual pain.

Research background

Our technologies are grounded in more than three decades of foundational research. A selection of papers, some written by our team and our advisors, and others from the broader community, can be found below.

Dutra, L. (et al)
2020
Modulating Anxiety and Functional Capacity with Anodal tDCS Over the Left Dorsolateral Prefrontal Cortex in Primary Dysmenorrhea
Rodrigues, Y. (et al)
2024
Clinical usability study of a home-based self-administration transcranial direct current stimulation for primary dysmenorrhea: A randomized controlled trial
Stiernam, L. (et al)
2023
Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids
Chase, H. (et al)
2020
Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation
94%

Feel better in just three months.

Our mission is to empower women to take ownership of their cycle.