Endometriosis
A brain-based perspective
Chronic inflammation
Endometriosis is a chronic inflammatory condition where tissue similar to the uterine lining grows outside the uterus - usually in the pelvis, but sometimes beyond. These growths can cause pain, fatigue, and fertility challenges. It's now understood endometriosis affects not only the body, but also how the brain processes pain.
Highly prevalent
Endometriosis affects an estimated 1 in 10 women and people with periods -yet many go undiagnosed for years. Symptoms often begin in adolescence but are frequently dismissed or misunderstood, leading to an average delay of 7-10 years before diagnosis.
Range of treatment options
Diagnosis often involves pelvic exams, imaging, or laparoscopic surgery - though non-invasive methods are improving. Treatment options include hormonal therapies, pain management, and surgery. More recently, brain-based approaches that target the nervous system’s role in chronic pain are also being used.
Be in control of your endometriosis journey
Track symptoms across your cycle to spot patterns, understand flare-ups, and get insights that help you manage pain, mood, and energy.
Keep track in your own words
Discover patterns in your experiences
Integrate your data and your care plan
Bring loved ones on the journey
Targeted, regular relief from menstrual cycle pain.
Looking for pain relief without hormones, surgery, or side effects?
Nettle™ is a brain-based wearable designed to ease menstrual pain and emotional imbalance - two of the most common endometriosis-related challenges.
Nettle™ is a certified medical device, clinically proven to reduce menstrual pain.
It also helps support focus and emotional regulation in the lead-up to your period.
Your Nettle™ purchase includes a Samphire membership, including tools to track, learn and get support through every phase of your cycle.
Users with endometriosis are already experiencing improvements.
Our solutions are informed by neuroscience, and designed specifically for women's health. These are the experiences of people using them every day. Read all reviews
Feel better in just three months.
Our mission is to empower women to take ownership of their cycle.
Our mission is to empower women to take ownership of their cycle
Explore other brain-based perspectives
When it comes to healthcare, the brain is the missing link.