Premenstrual dysphoric disorder (PMDD)
A brain-based perspective
Severe hormonal sensitivity
PMDD is a cyclical mood disorder triggered by natural hormone fluctuations of the menstrual cycle. For those affected, the brain reacts abnormally to shifting levels of estrogen and progesterone - leading to intense mood changes, anxiety, irritability, and physical symptoms in the two weeks before a period.
Frequently misdiagnosed
PMDD affects an estimated 1 in 20 women and people with periods, but it's often mistaken for anxiety, depression, or “just PMS.” Symptoms are severe, yet many go years without a diagnosis or proper care for what they’re experiencing.
Treatment options
Diagnosis is usually made by tracking symptoms across multiple cycles. Treatments range from lifestyle support, SSRIs, and hormonal contraception or hormone replacement therapy (HRT). Newer brain-based approaches aim to support emotional regulation and reduce the nervous system’s reactivity to hormonal shifts.
Gain control of your PMDD journey
Track patterns, understand triggers, and access tools to help regulate mood, reduce overwhelm, and support your brain through each phase of your cycle.
Keep track in your own words
Discover patterns in your experiences
Integrate your data and your care plan
See your progress over time
Support for your cycle, when it's at its hardest.
Struggling with intense mood swings, brain fog, or emotional crashes before your period?
Nettle™ is a brain-based wearable designed to ease premenstrual pain and PMDD symptoms - helping you feel clearer, calmer, and more in control.
Nettle™ is a certified medical device, clinically proven to reduce menstrual pain.
It also helps support focus and emotional regulation in the lead-up to your period.
Your Nettle™ purchase includes a Samphire membership, including tools to track, learn and get support through every phase of your cycle.
Women around the world are already experiencing improvements.
Our solutions are informed by neuroscience. These are the experiences of people using them every day. Read all reviews
Feel better in just three months.
Our mission is to empower women to take ownership of their cycle.
Our mission is to empower women to take ownership of their cycle
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