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It's all in your brain

EndoCyclic Therapeutics announces FDA IND for ENDO-205, the first non-hormonal peptide targeting the root cause of endometriosis.
Endometriosis, Latest Research, Pain and Cramps, NeuroscienceJanuary 1, 1970

ENDO-205: the first non-hormonal endometriosis treatment enters clinical trials

The FDA cleared the first non-hormonal drug candidate for endometriosis to enter clinical trials. We explain what ENDO-205 is, why non-hormonal options matter, and what else is in the pipeline for people who can't or won't take hormonal treatments.

Gold ribbon illustration representing suicide awareness and prevention.
Latest Research, PMDD, Mental HealthMay 13, 2026

PMDD and suicidality: finally the evidence for what millions know to be a lived experience

A major systematic review covering more than 2.6 million people confirms that suicidal thoughts, planning, and attempts are significantly more common in people with PMDD, and that no treatments have yet been studied to address this risk.

new-york-times-flow
Research, Mental Health, Neuroscience, NeuroplasticityApril 29, 2026

Could at-home brain stimulation reduce SSRI reliance?

A new 2026 New York Times feature follows Flow's FDA approval to ask whether at-home brain stimulation could give psychiatry an alternative to SSRIs...here's what it tells us.

Woman at home using a small wireless TENS device on her lower abdomen.
Research, Endometriosis, Pain and CrampsApril 21, 2026

New 2026 research on TENS for endometriosis: what the study shows - and doesn't

New 2026 research from Penn State tested at-home TENS - the mechanism behind devices like Livia, Ovira, and Myoovi for endometriosis pain. Quality of life improved and ibuprofen use dropped, but the primary pain outcome didn't move. Here's what that means for people with endometriosis, period cramps, and chronic pelvic pain.

Woman at home in contemplative repose wearing a minimalist consumer EEG headband, representing brain-sensing technology for the menstrual cycle.
Research, Menstrual Cycle, Neuroscience, Mental Health, Hormonal HealthApril 21, 2026

Your brain changes with your cycle: what a 2026 EEG review found

A new 2026 systematic review pulled together 23 resting-state EEG studies across the menstrual cycle. Alpha and theta brain activity shift reliably with hormones - likely reflecting real changes in attention, emotional well-being, and how the brain processes the self. Here's what the evidence actually shows, and what it still can't tell us.

Close-up illustration of neurons and synaptic connections in the brain, showing the neural pathways involved in GABA signaling and mood regulation.
PMDDApril 20, 2026

Why your brain reacts differently to progesterone: the ALLO theory of PMDD

After ovulation, your body converts progesterone into a neurosteroid called allopregnanolone (ALLO). For most people, ALLO boosts GABA, the brain's calming signal, and that's that. But researchers at Umeå University in Sweden have found that some women's brains respond to ALLO in the opposite direction, with anxiety and low mood instead of calm.