Our brains run on electricity.
Electrical rhythms in your brain shape how you think, feel, and respond to the world.
Samphire's therapeutics support your brain when these rhythms are hardest to regulate across your cycles.
As hormones rise and fall, the electrical patterns in your brain change in response.
Your cycles can imbalance your brain.
Menstruation, menopause and postpartum (the period after pregnancy) are hormonal cycles that many women experience. While occuring in different life stages, these cycles are similar in that they all cause significant hormonal changes that can affect your brain.
These changes are usually subtle. But sometimes they are too strong, too fast, or arrive at the wrong moment — throwing your brain's activity out of balance.
Imbalance can change how you feel.
Depending on where in your brain this imbalance occurs, you can experience different things: symptoms such as mood swings, anxiety, depression, or changes in your physical sensations.
For most people, these hormonally driven imbalances in the brain are most common in the prefrontal cortex and in the motor cortex.
The prefrontal cortex (near your forehead) plays a central role in mood, decision-making, and emotional control. It helps you stay steady under stress, feel motivated, stay focused, and experience joy — all by coordinating signals across deeper emotional and reward circuits in the brain.
The motor cortex (near the top middle of your head) plays a key role in how your body processes pain and physical tension. It works in concert with deeper sensory regions of the brain to regulate how strongly you experience physical sensations and to maintain a healthy level of control over pain signals - like those from cramping, headaches or bloating.
It is normal to feel physical and mental change across your cycle. But when these changes coincide with moments of increased sensitivity in the brain, otherwise normal sensations can escalate quickly — feeling sharper, more overwhelming, or harder to manage than usual. Not because anything is wrong in the body, but because the circuits that normally regulate pain and physical sensations are temporarily more reactive.
Bloating
Brain Fog
Cramping
Headache
Low Self Esteem
Track and respond to your experiences around the cycle in the Samphire app, powered by proprietary CycleSync™ technology.
Download the Cycle Brain Guide
Learn from Samphire's science team how your brain changes across your cycle and discover science-backed strategies to work with your natural rhythms.
This is women's healthcare reimagined. Thoughtful, accessible, and grounded in data that finally centres women's lived experiences.
Dr. Emilė Radytė, Samphire's CEO
Nettle™ and Lutea™: Restoring balance with neurostimulation.
The first neurostimulation devices designed for women, including the shape of the head, common hairstyles, and the practical realities of daily life that traditional devices were never built to accommodate.
Neuroscience shows that gentle, targeted stimulation can strengthen the very networks affected by cyclical hormonal changes — offering a way to reinforce stability without disrupting the natural rhythm of the cycle.
Both Nettle™ and Lutea™ deliver gentle, targeted stimulation to the brain, at the right time and in the right amount. They both use the exact same proprietary technology, are designed to work seamlessly with other interventions, and are clinically validated.
Clinically validated technology designed for you.
For the first time, treatment is now convenient and at-home, removing the need for clinic visits, scheduling hurdles, or costly medical setups.
Neurologists, psychiatrists, and neuroscientists have spent decades mapping how different regions of the brain respond to subtle shifts in electrical activity — and how targeted stimulation can strengthen circuits involved in mood, focus, and pain processing. Their work laid the foundation for both Nettle™ and Lutea™.
Six Month User Survey
Real-world outcomes reported by users six months after using Nettle™.
0%
stop or reduce their medications.
0%
reduce hormonal treatments.
0.0
healthcare appointments avoided per user per year.
The WIND Trial
Nettle™'s neurostimulation assessed against a placebo control group, assesssing for pain and mood relief.
0%
found Nettle™ easy to integrate into their lives
0%
noticed mood improvements within one cycle
0%
experienced reduced pain within one cycle
Our Clinical Studies
Together with our partners, we're gathering clinical data on the women whose brains and bodies were historically excluded from research.
We work with partners from the following institutions:
Keep exploring the science
Lutea™ and Nettle™'s science
Understand the neurostimulation science behind Lutea™ and Nettle™, and how it is optimised for women's health outcomes.
Our studies
Active studies we are running with leading partners around the world.
Research background
Explore the broad base of third party research related to neurostimulation and women's health.
Collaborate with us
We're committed to closing the research gap in women's health, and collaborate with leading researchers around the world.