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The power to transform your cycle lies in your brain.

Nettle is the world's first medical-grade neuromodulation wearable for PMS and menstrual pain.

The power to transform your cycle lies in your brain.

Nettle is an award-winning wearable that uses advanced neurotechnology to reprogram how your brain perceives pain and mood symptoms.

The Future of Menstrual Care

Using advanced neurotechnology, Nettle improves your menstrual cycle health by transforming your brain’s neural networks. Experience results in one cycle, regain control over your life in three.

The world’s first medical-grade, drug and hormone-free solution for managing PMS and menstrual pain.

Non-invasively targets the most common and severe mood and pain symptoms at their source in the brain.

Backed by over 30 years of clinical research, outperforming traditional treatments in our trials.*

Built to fit into your routine with sessions for just 20 minutes a day, 5 days a month.

* At-home Treatment of Primary Dysmenorrhea using a Wearable IoT Neuromodulation Device: A Triple Blind, Randomised Sham-Controlled Trial). See the results here.

Reduces menstrual pain

Improves low mood

Tested in placebo-controlled trials

Drug and hormone free

Clinic grade technology

Feel Your Best in Every Phase

Sign up to explore the world’s first brain stimulation device for PMS and menstrual care, and receive exclusive neuroscience-backed content about the connection between your cycle and brain.

By clicking Sign Up you're confirming that you agree with our Terms and Conditions.
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“What if there was a drug-free and effective way to manage both menstrual pain and mood disorders?”

Get your money back if Nettle doesn’t work for you

We spent over three years conducting research and rigorous clinical testing to develop Nettle, and we believe in the quality and efficacy of our technology. However, we understand that Nettle may not be for everyone. That’s why we offer a 90-day trial policy to let users experience Nettle across multiple cycles.

If you’ve followed the recommended guidelines and still feel Nettle isn’t right for you, you may return it for a full refund.

DISCLAIMER

Throughout our communications, we use the word women to include all people experiencing menstrual-related issues, including but not limited to all people assigned female at birth.

ENGINEERED FOR WOMEN

Nettle uses brain stimulation to target brain regions responsible for pain perception and mood regulation.

Its underlying technology has been clinically validated in managing pain, depression, anxiety, cognitive function and performance through over 30 years of research.

What does Nettle do?

Modulates neuronal excitability

Neuronal excitability is the ability of brain cells (neurons) to respond to stimuli and convert these into electrical impulses, crucial for everything from motor responses to complex thinking and memory. Proper regulation of neuronal excitability is essential for brain health. Abnormal levels can lead to neurological disorders, such as depression, where certain brain areas become underactive. Nettle employs low-current electrical pulses to adjust neuronal excitability, helping adjust these imbalances.

Rebalances activity in your brain

During the luteal phase of your menstrual cycle, rising progesterone levels lead to changes in brain activity. These hormonal fluctuations are associated with alterations in mood, increased irritability, and cognitive shifts. Targeted brain stimulation, particularly applied to the dorsolateral prefrontal cortex (DLPFC), has been shown to mitigate these changes by normalising brain activity to levels observed during the pre-luteal phase.

Regenerates neural pathways

By applying a low-intensity electrical current to the brain, Nettle enhances neuroplasticity—the brain's ability to form and reorganize synaptic connections. This promotion of neuroplasticity ensures that Nettle's effects are lasting, leading to improvements in the brain's processing of pain and mood. These improvements can yield long-term benefits and reduce reliance on medications.

By targeting the brain, Nettle reprograms how you perceive pain and regulate mood.

After just one month’s use, our clinical trial users reported:

Reduction in menstrual pain

The average reduction in menstrual pain was 53%. This decrease continued over time, suggesting that the most significant reduction could be expected after 3 months of consistent use. Remarkably, over 44% of women reported minimal period pain (rated under 2 out of 10) after just one month of using Nettle. For comparison, painkillers typically only reduce pain by 45-53% on average¹, and it's estimated that at least 18% of women obtain no relief from NSAIDs².

Improvements in low mood

During the PMS period, the average symptoms of low mood improved by 34%. Impressively, 100% of users with extremely severe low mood symptoms (PANAS score above 25) reported a shift to moderate or mild symptoms after just one month of using Nettle. Furthermore, the relief from low mood symptoms extended for an additional month after discontinuation of Nettle, indicating potential long-term improvements with continued use.

Boosts in functionality

The average functionality, or fitness status, improved by 11%. This improvement is primarily attributed to reductions in pain and anxiety, as well as enhancements in mood, which collectively lead to increased activity levels. These benefits were directly associated with the use of Nettle and tended to diminish during the follow-up period, suggesting they are not directly brain-based effects but rather secondary effects of improvements in overall brain health and plasticity.

Feel Your Best in Every Phase

Sign up to explore the world’s first brain stimulation device for PMS and menstrual care, and receive exclusive neuroscience-backed content about the connection between your cycle and brain.

By clicking Sign Up you're confirming that you agree with our Terms and Conditions.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Your journey is supported by a neuroscience-backed app

Nettle is managed through the Samphire Neuroscience mobile app, which syncs with your health data for a personalised experience. The app will offer cycle tracking and symptom logging features as well as neuroscientific content to support your journey toward a healthier cycle-brain connection.

CYCLE TRACKING
SYMPTOM LOGGING
NEUROSCIENCE CONTENT
PERSONALISED CALENDAR
COGNITIVE TRACKING
GUIDED NEUROMODULATION
FORGING A NEW PATH

Why should you try brain stimulation?

Brain stimulation for menstrual symptom management offers a non-invasive, drug-free alternative that directly targets the neural pathways involved in pain and mood regulation.

Non-invasive, Drug and Hormone Free

Nettle offers a natural, non-invasive way to ease relieve and mood symptoms by enhancing brain function and adaptability in key areas. Using gentle, low-current pulses that mimic the brain’s natural energy, it optimises brain and cycle health without relying on painkillers, SSRIs or hormonal contraception.

Outperforms traditional treatments

Backed by four clinical trials, Nettle has proven to be a safe and highly effective alternative. In our Triple-Blind, Randomised Sham-Controlled Trial, Nettle surpassed traditional treatments in managing pain, mood, and overall functionality.

Targeted relief

Through precision design, brain stimulation devices can target specific brain regions associated with various mental and physical symptoms, while leaving the rest of the brain and body untouched. In doing so, it addresses symptoms directly at their source, enabling a more efficient and effective treatment process.

Start Your Journey With Nettle Today

Our early users can try Nettle risk free for 90-days, allowing you to experience the difference before committing.

What's included
Nettle wearable headband for at-home use and accessories
Dedicated support 7 days a week in-app and over email to get you started.
Year membership to our CycleSync app for early adopters.
1 Year Supply of Refills (Electrode Covers and Salt Sachets).
Total
£449
inc £74.83 VAT
or £149.66/month for three months with 0% interest from PayPal*
Buy Nettle Now
90 day trial policy
Free express delivery
Add a promo code on the next page.

Nettle outperforms traditional treatments in clinical trials.

Below are the results from our WIND* trial, A Triple-Blind, Randomised Sham-Controlled Trial, that focused on three metrics: pain, mood, and average functionality or fitness status.

AFTER 30 Days*

100%

of users with severe low mood symptoms improved to moderate or mild low mood symptoms.

72%

of users reported clinically significant pain relief.

67%

of users reported a clinically significant improvement in their average functionality, or fitness status.

91%

of users reported Nettle was easy to integrate into their daily routine.

*Have a detailed look at our trial results here.

Our users have felt the difference.

Nettle might be new to the market, but early users have already commented on its life-changing benefits. Here’s what they have to say.

For the first time in years, I feel like I’ve regained a sense of control over my life.
“I am absolutely amazed by Nettle! After just seven sessions, I’ve noticed a remarkable positive effect, especially emotionally. Normally, I struggle with depression, self-doubt, and a significant lack of energy right before my period—but this time, none of that! Instead, I feel empowered, confident, and full of energy. Even my period itself was less painful; for the first time, I didn’t need painkillers (and I usually rely on 2-3 ibuprofen). The pain was manageable, and that alone is a huge relief.”
Alexandra
25.10.2024
It is truly a life-changing creation (if you are a woman suffering from PMS of course).
"I’ve been using the Nettle headband by Samphire Neuroscience almost since it’s launch and it’s made a remarkable difference to my depression and anxiety that I experience as a result of PMDD. I have a long cycle and experience 2 weeks of PMDD that used to feel completely unmanageable, when I use Nettle from ovulation onwards I experience a significant reduction in symptoms. I’ve also tried other treatments including antidepressants and TMS but none have been as effective in alleviating some of my symptoms.”
FB
15.05.2024
I’ve also tried other treatments including antidepressants and TMS but none have been as effective
"I have been using Nettle for almost a year and it is truly a life-changing creation (if you are a woman suffering from PMS of course). It has not only helped me to become more aware and be more in tune with my body, but made me more conscious about my bodily sensitivity. It's fascinating how our bodies work and I hate to think I used to heavily fill it with painkillers every month."
Džiuginta Mažulytė
03.04.2024

Using Nettle is easy

Nettle is designed specifically for women, making it the first brain stimulation device created to be discreet. Setup takes under 2 minutes, and each session lasts just 20 minutes.

1. Insert covers.

2. Soak covers.

3. Put Nettle on.

4. Connect and enjoy.

Built on verified science

Nettle was built on over 30 years of research in the fields of chronic pain and depression management. Have a look at some of the key papers that validate our technology.

Transcranial direct current stimulation to reduce chronic pelvic pain in endometriosis: Phase II Randomized Controlled Clinical Trial

S Mechsner, et al., Pain Medicine (March, 2023).

Safety of transcranial Direct Current Stimulation: Evidence Based Update 2016

M Bikson, et al., Brain Stimulation ( 2016 ).

Development and testing of a novel IoT consumer tDCS device for the treatment of primary dysmenorrhea

E Radyte, et al., Brain Stimulation Journal (January, 2023).

Depression, anxiety, stress, and dysmenorrhea: a protocol for a systematic review

AH Pakpour et al., Systematic Reviews (March, 2020).

Altered cognitive control network mediates the association between long-term pain and anxiety symptoms in primary dysmenorrhea

Z Yu et al., NeuroReport (January, 2024).

Premenstrual dysphoric disorder and changes in frontal alpha asymmetry

E Baehr et al., International Journal of Psychophysiology (2004).

Modelling and Preliminary Clinical Validation of Home-based Menstrual Neuromodulation Therapy

E Radytė et al., Preprint (February, 2024)

Evidence-Based Guidelines and Secondary Meta-Analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric Disorders

F Fregni, et al., International Journal of Neuropsychopharmacology ( April, 2021 )

Effects of Transcranial Direct Current Stimulation for Treatment of Primary Dysmenorrhea: Preliminary Results of a Randomized Sham-Controlled Trial

R Pegado, et al., Pain Medicine (December, 2020)

Modulating Anxiety and Functional Capacity with Anodal tDCS Over the Left Dorsolateral Prefrontal Cortex in Primary Dysmenorrhea

L Dutra et al, International Journal of Women's Health (2020)
Meet

Our scientific experts

Dr. Sanjula Dhillon Singh
Neurosurgeon

Neurosurgeon focused on global public health. Also the founder of the podcast called ‘Science with Sanjula’ where she interviews world-leading scientists about big issues in global healthcare. She is helping Samphire translate our science into public impact.

Professor Maria Theresa Micussi
Women’s Health Researcher

Researcher from Universidade Federal do Rio Grande do Norte focused on neglected women's health conditions. Responsible for running Samphire's clinical trials.

Professor Rodrigo Pegado
Chronic Pain Expert

World-leading chronic pain researcher from Universidade Federal do Rio Grande do Norte. He was the first person in the world to publish a paper on the topic of tDCS to treat pain in dysmenorrhea (menstrual pain).

Dr. Marie Christine Nizzi
Psychologist and Researcher

Pyschologist and world-leading researcher on innovative clinical interventions. Currently the president of Harvard Alumni for Mental Health and is responsible for developing Samphire's cognitive science-based interventions.

Professor David Silbersweig
Professor of Neuropsychiatry

Professor of Neuropsychiatry at Harvard and global PMDD neuroanatomy expert. He worked on one of the first pieces of research that showed that PMDD is a neurobiological condition, which laid the foundation for PMDD being recognised by the International Classification of Diseases.

Dr. Edward Evantash
Chief Medical Officer

Edward Evantash is a highly experienced and accomplished professional in the medical field, having held various leadership positions in multiple companies. Prior to his current roles, Edward served as Medical Director and V.P. Global Medical Affairs at Hologic and held prominent positions at Tufts Medical Center.

FAQs

If you have a question about Nettle or it’s launch, and we haven’t answered it here on our main FAQ page, please don’t hesitate to get in touch.

Are there any contraindications?

There are important contraindications that apply to using Nettle. If any of the below contraindications apply to you, you should not use Nettle.

  • Persons who are under 18 years old.
  • Persons with a history of seizures or epilepsy.
  • Persons who are pregnant or may be pregnant.
  • Persons experiencing active suicidal thoughts.
  • Persons with a pre-existing neurological or neuropsychiatric condition.
  • Persons with a lesion, tumour or other defect in your skull, cranium or brain.
  • Persons with an implant inside their skull, cochlear implant or implanted hearing aid.
  • Persons with implanted medical devices, such as a cardiac pacemaker or neurostimulation devices, such as spinal cord stimulators, vagal nerve stimulators, auricular stimulators, or deep-brain stimulating electrodes.

If you are unsure about whether any contraindications apply to you, you must consult with your physician before continuing, especially if you are under the care of a physician for any conditions related to the central nervous system (e.g. neurology, psychiatry).

Have you tested Nettle on women of colour?

Yes! 47.1% of participants in our clinical trials self-identified as women of colour, 67.6% of them had wavy, curly or coily hair, and trial participants had a BMI range from 19 to 29. 

How much does Nettle cost?

Nettle will cost £449 in the UK at the time of launch. This price reflects the extensive clinical research and testing Nettle has undergone to be a medically approved and clinically validated health technology device. We will be offering payment plans to all customers and exclusive discounts for waitlist members.

I have PMDD, is Nettle for me?

Premenstrual dysphoric disorder (or PMDD) is a serious condition that - like much of women’s health - has been largely ignored by research, clinicians and solutions for too long. PMDD is a complex condition, with complex symptomatology, and women with PMDD do not necessarily have the same symptoms or experiences.

Nettle has been designed specifically with women in mind who have certain types of PMDD symptoms, especially low mood; and it may be worth exploring as an option alongside other treatment options. However, Nettle has not yet been tested on exclusively PMDD patient populations, and we’re currently investigating such benefits in a separate clinical trial.

How does Nettle work?

During your luteal phase, fluctuations occur in certain brain regions which contribute to symptoms of PMS and menstrual pain such as low mood, anxiety, brain fog and cramps.
Your brain runs on electricity, and neurons communicate using electrical signals called action potentials. Nettle uses the natural language of neurons to rearrange and regenerate neural pathways - a process known as neuroplasticity. This is done by administering safe and small electrical pulses to brain regions where these fluctuations occur. We are able to target them via the placement of the electrodes on the headband, one targeting your dorsolateral prefrontal cortex (DLPFC) and the other targeting your insula via your motor cortex (M1).

This stimulation gets neurons firing in a way that is more consistent with follicular phase activity, empowering you to feel your best even during the premenstrual phase. The technology Nettle employs is well-known and validated from the fields of depression and chronic pain treatment.

Have you conducted research with Nettle?

Yes, extensively.

We have run more than two years of tests on Nettle itself, and this builds on decades of research into the underlying neurotechnology and its mechanisms. These tests range across safety, efficacy, ergonomics, and more. The results of our WIND trial are available on our website and demonstrate significant improvement in low mood, pain and function after using Nettle for just 5 days, which is equivalent to one cycle.

We are in the process of setting up and conducting more trials, including one with the NHS that will test the efficacy of Nettle amongst patients with endometriosis and other trials for PMDD, among other conditions.

What symptoms is Nettle designed to manage?

Nettle is designed to help manage a variety of physical and psychological symptoms. Physical symptoms include menstrual pain and cramping, while psychological symptoms encompass low mood, irritability, anger management, mood instability, and brain fog. There is stronger evidence supporting Nettle's effectiveness for certain symptoms compared to others.

The technology behind Nettle has been rigorously tested in multiple clinical trials and continues to be assessed in ongoing studies to evaluate its effectiveness across various clinical endpoints.

Is Nettle safe?

Yes, Nettle has been rigorously tested for safety, and its underlying technology is supported by over 30 years of evidence demonstrating its safety for both short- and long-term use. However, as with all medical technologies, Nettle may not be suitable for everyone. The key contraindications for using Nettle are diagnoses and history of epilepsy and/or seizures, and any pre-existing neurological implants, which could interfere with Nettle’s mechanism of action.

Blog

Learn more about the cycle brain connection

Explore our blog where we break down neuroscience, menstrual health, and the cycle-brain connection.

November 6, 2024

The Neuroscience of Endometriosis

While traditionally viewed as a gynaecological disorder, recent research has revealed a deeper, more complex link between endometriosis and the brain.
November 6, 2024

The Neuroscience of 
Perimenopause

While the clinical definition of perimenopause focuses on reproductive system changes, many of the symptoms are actually neurological, impacting mood, sleep, and cognition.
October 10, 2024

That Time of the Month

You know what we’re talking about—the days leading up to your period when you often feel low, irritable, and maybe find yourself arguing with your partner more.
August 23, 2024

The Hidden Game Changer

In recent years, a growing number of elite athletes have broken their silence about a topic long considered taboo in the world of sport - their menstrual cycles.
March 20, 2024

The Menstrual Pain-Brain Connection

Pain is not just a symptom. It's a complex experience deeply influenced by biological, psychological, and social factors. Pain is also notoriously difficult to measure - and...
February 26, 2024

Neuroplasticity as a Tool for Optimising Menstrual Health

For centuries, the prevailing belief was that the adult brain was immutable to change. The concept of neuroplasticity—the brain's ability to change functionally or structurally...
November 16, 2023

Will Neuroimaging Revolutionise the Diagnosis of PMDD?

Despite its impact, it takes an average of 20 years for women to be accurately diagnosed with PMDD. The diagnosis is fraught with unique challenges, which include...
October 30, 2023

Periods, Productivity, and the Path to Progress

The statistics are glaring: menstrual symptoms undeniably influence productivity. However, while these numbers are revealing, capturing the full spectrum of menstrual symptoms...
October 17, 2023

The Problem with Painkillers: They Weren't Made for Women

Over 90% of women continue to grapple with menstrual cramps using an unevolved, 1980s-era solution: over-the-counter (OTC) painkillers. This makes even less sense when you look...
September 29, 2023

Women with Severe PMS and PMDD Experience Depression-Like Symptoms Every Month

An increasing number of clinical studies are examining the brain in relation to the menstrual cycle, with a particular focus on women with severe PMS symptoms or Premenstrual...
Blog

Learn more about the cycle brain connection.

Explore our blog where we break down neuroscience, menstrual health, and the cycle-brain connection.

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